The science links variations in the DNA to disease profiles. In DNA, a distinction can be made between animals that are healthy and animals that are carrier of or affected by a particular hereditary disease. The gene and position in which a mutation in the DNA has occurred and caused the hereditary disease can also be mapped. Through comparison of the symptoms of a disease with variation in the DNA, a diagnostic test is proved. This normally leads to publication in a scientific article. These articles are often based on a single breed.
All available DNA tests are described in the OMIA database (Online Mendelian Inheritance in Animals) by Australian professor Dr Frank Nicolas.
CombiBreed has a wide range of DNA tests available to determine whether an animal is a carrier of or affected by a hereditary disease. CombiBreed therefore offers breeders the option to make use of this knowledge when choosing a breeding partner for their breeding animal(s). In this way, the birth of offspring that will suffer from a hereditary disease can be avoided and animal welfare can be improved.
If the result of a DNA test suggests that an animal is affected (two copies of the mutation), this is normally the basis to assume that an animal will develop the hereditary disease. If the result of a DNA test indicates that an animal is not a carrier of the mutation that causes a specific disease profile, this is not a guarantee that the animal will never develop this hereditary disease, as mutations in other parts of the DNA could occur, which cause the same disease profile.
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